| 货号 | 0811/50 |
| 供应商 | Tocris |
| 生物活性 | A potent blocker of glutamate transport; selective for EAAT2 and EAAT4 (IC50 values are 90, 109, 1600 and 1080 μM for EAAT2, EAAT4, EAAT1 and EAAT3 respectively). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 161.16 |
| 分子式 | C6H11NO4 |
| 可溶性/溶解性 | Soluble to 100 mM in 1eq. NaOH |
| 参考文献 | Eliasofet al (2001) Pharmacological characterization of threo-3-methylglutamic acid with excitatory amino acid transporters in native and recombinant systems. J.Neurochem. 77 550. PMID: 11299317. Mitrovicet al (1998) Identification of functional domains of the human glutamate transporters EAAT1 and EAAT2. J.Biol.Chem. 273 14698. PMID: 9614067. Vandenberget al (1997) Contrasting modes of action of methylglutamate derivatives on the excitatory amino acid transporters, EAAT1 and EAAT2. Mol.Pharmacol. 51 809. PMID: 9145919. |