| 货号 | 0542/50 |
| 别名 | (±)-1-(5-Isoquinolinesulphonyl)-2-me |
| 供应商 | Tocris |
| 生物活性 | Protein kinase inhibitor. IC50 values for inhibition of PKC, PKG, PKA and myosin light chain kinase are 6.0, 5.8, 3.0 and 97.0 μM respectively. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 364.29 |
| 分子式 | C14H17N3O2S.2HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 20 mM in DMSO |
| CAS号 | 84477-87-2 |
| 参考文献 | Quicket al (1992) The structure and biological activities of the widely used protein kinase inhibitor, H7, differ depending on the commercial source. Biochem.Biophys.Res.Commun. 187 657. PMID: 1530632. Ratzet al (1990) Effect of the kinase inhibitor, H-7, on stress, crossbridge phosphorylation, muscle shortening and inositol phosphate production in rabbit arteries. J.Pharmacol.Exp.Ther. 252 253. PMID: 2299593. Hidakaet al (1984) Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry 23 5036. PMID: 6238627. |