| 货号 | 15576-1mg |
| 描述 | Becatecarin is a water-soluble, diethylaminoethyl analog of the antineoplastic antibiotic rebeccamycin.1 It intercalates into DNA, stabilizing the DNA-topoisomerase complex.2 This results in the potent catalytic inhibition of both topoisomerases I and II, initiating DNA cleavage and apoptosis.2 Becatecarin, alone or in combination with other compounds, has anti-cancer as well as myelosuppressive effects in vivo.3,4 It is also a transport substrate of the ATP-binding cassette (ABC) transporter ABCG2.5 |
| 别名 | BMS 181176;BMY 27557;NSC 655649;XL 119; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kaneko, T.,Wong, H.,Utzig, J., et al. Water soluble derivatives of rebeccamycin. J.Antibiot.(Tokyo) 43(1), 125-127 (1990). 2.Long, B.H.,Rose, W.C.,Vyas, D.M., et al. Discovery of antitumor indolocarbazoles: Rebeccamycin, NSC 655649, and fluoroindolocarbazoles. Curr.Med.Chem.Anticancer Agents 2, 255-266 (2002). 3.Ricart, A.D.,Hammond, L.A.,Kuhn, J.G., et al. Phase I and pharmacokinetic study of sequences of the rebeccamycin analogue NSC 655649 and cisplatin in patients with advanced solid tumors. Clinical Cancer Research 11(24 Pt 1), 8728-8736 (2005). 4.Schwandt, A.,Mekhail, T.,Halmos, B., et al. Brief report: Phase II trial of rebeccamycin analogue, a dual topoisomerase I and II inhibitor, in relapsed "sensitive" small cell lung cancer. J.Thorac.Oncol. 7(1), 751-754 (2012). 5.Robey, R.W.,Obrzut, T.,Shukla, S., et al. Becatecarin (rebeccamycin analog, NSC 655649) is a transport substrate and induces expression of the ATP-binding cassette transporter, ABCG2, in lung carcinoma cells. Cancer Chemotherapy and Pharmacology 64(3), 575-583 (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 669.6 |
| 分子式 | C33H34Cl2N4O7 |
| CAS号 | 119673-08-4 |
| 稳定性 | ≥ 1 year |
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