| 货号 | 11969-50mg |
| 描述 | (+)-Etomoxir is an irreversible inhibitor of carnitine palmitoyltransferase 1, a mitochondrial enzyme involved in fatty acid β-oxidation (IC50 = 5-20 nM in rat liver).1,2 By regulating fatty acid oxidation, (+)-etomoxir has the potential to affect ketogenesis, cholesterol synthesis, and gluconeogenesis.3,4 (+)-Etomoxir has also been identified as a direct agonist of PPARα.1,5 |
| 别名 | (R)-(+)-Etomoxir; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Portilla, D.,Dai, G.,Peters, J.M., et al. Etomoxir-induced PPARα-modulated enzymes protect during acute renal failure. Am.J.Physiol.Renal.Physiol. 278(4), F667-F675 (2000). 2.Lopaschuk, G.D.,Wall, S.R.,Olley, P.M., et al. Etomoxir, a carnitine palmitoyltransferase I inhibitor, protects hearts from fatty acid-induced ischemic injury independent of changes in long chain acylcarnitine. Circulation Research 63(6), 1036-1043 (1988). 3.Luiken, J.J.,Niessen, H.E.,Coort, S.L., et al. Etomoxir-induced partial carnitine palmitoyltransferase-I (CPT-I) inhibition in vivo does not alter cardiac long-chain fatty acid uptake and oxidation rates. Biochemistry Journal 419(2), 447-455 (2009). 4.Xu, F.Y.,Taylor, W.A.,Hurd, J.A., et al. Etomoxir mediates differential metabolic channeling of fatty acid and glycerol precursors into cardiolipin in H9c2 cells. Journal of Lipid Research 44(2), 415-423 (2003). 5.Skorin, C.,Necochea, C.,Johow, V., et al. Peroxisomal fatty acid oxidation and inhibitors of the mitochondrial carnitine palmitoyltransferase I in isolated rat hepatocytes. Biochemistry Journal 281 (Pt 2), 561-567 (1992). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 320.7 |
| 分子式 | C15H18ClO4 • Na |
| CAS号 | 828934-41-4 |
| 稳定性 | ≥ 2 years |
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