20-carboxy Leukotriene B4
货号：
20180-100ug 基本售价：
7112.0 元 规格：
100 ug
产品信息
概述| 货号 | 20180-100ug |
| 描述 | 20-carboxy LTB4 is a metabolite of LTB4 in human neutrophils. In human leukocytes, LTB4 is inactivated by the enzyme LTB4 20-hydroxylase. The resulting 20-hydroxy LTB4 is further oxidized to 20-carboxy LTB4.1LTB4 metabolism in isolated rat hepatocytes also results in production of 20-carboxy LTB4 along with other ω-oxidation products.2 The biological activity of 20-carboxy LTB4 is only about 2.6% compared to that of LTB4 in causing PMNL degranulation.3 |
| 别名 | 20-carboxy LTB4; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hansson, G.,Lindgren, J.Å.,Dahlén, S.E., et al. Identification and biological activity of novel w -oxidized metabolites of leukotriene B4 from human leukocytes. FEBS Letters 130, 107-112 (1981).
2.Harper, T.W.,Garrity, M.J. and Murphy, R.C. Metabolism of leukotriene B4 in isolated rat hepatocytes. Identification of a novel 18-carboxy-19,20-dinor leukotriene B4 metabolite. The Journal of Biological Chemisty 261, 5414-5418 (1986).
3.Feinmark, S.J.,Lindgren, J.Å.,Claesson, H.E., et al. Stimulation of human leukocyte degranulation by leukotriene B4 and its ω-oxidized metabolites. FEBS Letters 136, 141-144 (1981).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥97% |
| 计算分子量 | 366.5 |
| 分子式 | C20H30O6 |
| CAS号 | 80434-82-8 |
| 稳定性 | ≥ 2 years |
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