| 货号 | 10186-1ea |
| 描述 | The Cayman COX Inhibitor Pack contains a combination of frequently used cyclooxygenase (COX) inhibitors. Each kit contains aspirin, the archetype nonselective, irreversible COX inhibitor.1 A series of COX-2 selective inhibitors are available in the COX-PAK, including NS-398, one of the first reported and most widely used.2 Another COX-2-selective inhibitor included is CAY10404, with nearly 500,000-fold COX-2 selectivity.3 The potent COX-1-selective inhibitor SC-560 is an example of a reversible, diaryl heterocycle COX-1 inhibitor with low nM activity.4 Also included is valeroyl salicylate, an irreversible alkylator of COX enzymes with some selectivity toward COX-1.5 Resveratrol is also included in the COX-PAK due to its complex activities, which include COX inhibition, peroxidase inhibition, antioxidant activity, and gene regulation.6,7 |
| 别名 | Cyclooxygenase-PAK; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Vane, J.R., and Botting, R. Inflammation and the mechanism of action of anti-inflammatory drugs. The FASEB Journal 1, 89-96 (1987). 2.Futaki, N.,Takahashi, S.,Yokoyama, M., et al. NS-398, An new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro. Prostaglandins 47, 55-59 (1994). 3.Habeeb, A.G.,Rao, P.N.P., and Knaus, E.E. Design and syntheses of diarylisoxazoles: Novel inhibitors of cyclooxygenase-2 (COX-2) with analgesic-antiinflammatory activity. Drug Development Research 51, 273-286 (2000). 4.Smith, C.J.,Zhang, Y.,Koboldt, C.M., et al. Pharmacological analysis of cyclooxygenase-1 in inflammation. Proceedings of the National Academy of Sciences of the United States of America 95, 13313-13318 (1998). 5.Bhattacharyya, D.K.,Lecomte, M.,Dunn, J., et al. Selective inhibition of prostaglandin endoperoxide synthase-1 (cyclooxygenase-1) by valerylsalicylic acid. Archives of Biochemistry and Biophysics 317, 19-24 (1995). 6.Johnson, J.L., and Maddipati, K.R. Paradoxical effects of resveratrol on the two prostaglandin H synthases. Prostaglandins & Other Lipid Mediators 56, 131-143 (1998). 7.Jang, M.,Cai, L.,Udeani, G.O., et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275, 218-220 (1997). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 稳定性 | ≥ 1 year |
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