Birinapant
货号：
19699-25mg 基本售价：
7084.0 元 规格：
25 mg
产品信息
概述| 货号 | 19699-25mg |
| 描述 | Birinapant is a bivalent mimetic of the Diablo homolog known as second mitochondria-derived activator of caspase (Smac). It is an antagonist of cellular inhibitor of apoptosis 1 (cIAP1, or BIRC2), cIAP2 (BIRC3), and XIAP (BIRC4), binding each at nanomolar concentrations.1 Birinapant causes rapid cIAP1 degradation, caspase activation, PARP cleavage, and NF-κB activation in breast cancer cells.1 It shows in vivo antitumor activity, inducing apoptosis in several types of cancer xenografts in mice.2,3 |
| 别名 | TL-32711; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Allensworth, J.L.,Sauer, S.J.,Lyerly, H.K., et al. Smac mimetic Birinapant induces apoptosis and enhances TRAIL potency in inflammatory breast cancer cells in an IAP-dependent and TNF-α-independent mechanism. Breast Cancer Res. Treat. 137(2), 359-371 (2013).
2.Krepler, C.,Chunduru, S.K.,Halloran, M.B., et al. The novel SMAC mimetic birinapant exhibits potent activity against human melanoma cells. Clin. Cancer Res. 19(7), 1784-1794 (2013).
3.Nguyen, Q.D.,Lavdas, I.,Gubbins, J., et al. Temporal and spatial evolution of therapy-induced tumor apoptosis detected by caspase-3-selective molecular imaging. Clin. Cancer Res. 19(14), 3914-3924 (2013).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 806.9 |
| 分子式 | C42H56F2N8O6 |
| CAS号 | 1260251-31-7 |
| 稳定性 | ≥ 2 years |
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