| 货号 | 15611-50mg |
| 描述 | CGP 37157 is a benzothiazepine that acts as a selective inhibitor of the mitochondrial sodium-calcium exchanger (IC50 = 0.36 μM in isolated mitochondria).1 It does not affect channels, exchangers, or ATPases on the cardiac sarcolemma or ATPases on sarcoplasmic reticulum.1 CGP 37157 is commonly used to study the role of mitochondrial-derived calcium in cytoplasmic calcium homeostasis.2,3 CGP 37157 inhibits sodium-dependent calcium efflux via the mitochondrial exchanger NCLX in a variety of cell types (IC50 = 5 μM).4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Cox, D.A.,Conforti, L.,Sperelakis, N., et al. Selectivity of inhibition of Na+-Ca2+ exchange of heart mitochondria by benzothiazepine CGP-37157. Journal of Cardiovascular Pharmacology 21(4), 595-599 (1993). 2.Baron, K.T. and Thayer, S.A. CGP37157 modulates mitochondrial Ca2+ homeostasis in cultured rat dorsal root ganglion neurons. European Journal of Pharmacology 340(2-3), 295-300 (1997). 3.White, R.J. and Reynolds, I.J. Mitochondria accumulate Ca2+ following intense glutamate stimulation of cultured rat forebrain neurones. Journal of Physiology 498(Pt 1), 31-47 (1997). 4.Palty, R.,Silverman, W.F.,Hershfinkel, M., et al. NCLX is an essential component of mitochondrial Na+/Ca2+ exchange. Proceedings of the National Academy of Sciences of the United States of America 107(1), 436-441 (2010). 5.Parnis, J.,Montana, V.,Delgado-Martinez, I., et al. Mitochondrial exchanger NCLX plays a major role in the intracellular Ca2+ signaling, gliotransmission, and proliferation of astrocytes. Journal of Neuroscience 33(17), 7206-7219 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 4 |
| 纯度 | ≥99% |
| 计算分子量 | 324.2 |
| 分子式 | C15H11Cl2NOS |
| CAS号 | 75450-34-9 |
| 稳定性 | ≥ 1 year |
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