| 货号 | 15591-50mg |
| 描述 | ICI 118551 is a potent, selective antagonist of the β2-adrenergic receptor (Ki = 0.7 nM for the β2receptor, compared with 49.5 and 611 nM for β1 and β3 receptors, respectively).1,2 It is active in vivo and is often used to evaluate the actions of adrenergic receptor agonists.3,4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hoffmann, C.,Leitz, M.R.,Oberdorf-Maass, S., et al. Comparative pharmacology of human β-adrenergic receptor subtypes--characterization of stably transfected receptors in CHO cells. Naunyn-Schmiedebergs Arch. Pharmacol. 369(2), 151-159 (2004). 2.Baker, J.G. The selectivity of β-adrenoceptor antagonists at the human β1, β2 and β3 adrenoceptors. Br. J. Pharmacol. 144(3), 317-322 (2005). 3.Deighton, N.M.,Motomura, A.,Bals, S., et al. Characterization of theβadrenoceptor subtype(s) mediating the positive inotropic effects of epinine, dopamine, dobutamine, denopamine and xamoterol in isolated human right atrium. Journal of Pharmacology and Experimental Therapeutics 262(2), 532-538 (1992). 4.Rothwell, N.J.,Stock, M.J. and Sudera, D.K. Changes in tissue blood flow and β-receptor density of skeletal muscle in rats treated with the β2-adrenoceptor agonist clenbuterol. British Journal of Pharmacology 90(3), 601-607 (1987). 5.Kim, I.M.,Tilley, D.G.,Chen, J., et al. β-blockers alprenolol and carvedilol stimulate β-arrestin-mediated EGFR transactivation. Proceedings of the National Academy of Sciences of the United States of America 105(38), 14555-14560 (2008). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 22 |
| 纯度 | ≥99% |
| 计算分子量 | 313.9 |
| 分子式 | C17H27NO2 • HCl |
| CAS号 | 72795-01-8 |
| 稳定性 | ≥ 2 years |
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