| 货号 | 18820-5g |
| 描述 | Cyclic AMP (cAMP) is a central second messenger in cell signaling, propagating signals from receptors to downstream pathways. It is generated from ATP by several adenylate cyclase enzymes, which are modulated by G protein-coupled receptors.1 cAMP activates protein kinase A and the exchange proteins activated by cAMP (Epac1 and Epac2), which are nucleotide exchange factors for the Rap family of GTPases.2,3 cAMP is degraded to AMP by cyclic nucleotide phosphodiesterases.4 |
| 别名 | Adenosine 3,5-cyclic monophosphate;cAMP;Cyclic adenosine monophosphate;NSC 94017;NSC 143670; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Dorsam, R.T. and Gutkind, J.S. G-protein-coupled receptors and cancer. Nature Reviews.Cancer 7, 79-94 (2007). 2.Shabb, J.B. Physiological substrates of cAMP-dependent protein kinase. Chemical Reviews 101, 2381-2411 (2001). 3.Breckler, M.,Berthouze, M.,Laurent, A.C., et al. Rap-linked cAMP signaling Epac proteins: Compartmentation, functioning and disease implications. Cellular Signalling 23(8), 1257-1266 (2011). 4.Scott, J.D.,Dessauer, C.W. and Tasken, K. Creating order from chaos: Cellular regulation by kinase anchoring. Annual Reviews of Pharmacology and Toxicology 53, 187-210 (2013). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 329.2 |
| 分子式 | C10H12N5O6P |
| CAS号 | 60-92-4 |
| 稳定性 | ≥ 2 years |
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