JP104
货号：
10008661-100mg 基本售价：
7056.0 元 规格：
100 mg
产品信息
概述| 货号 | 10008661-100mg |
| 描述 | The enzyme, fatty acid amide hydrolase (FAAH), is widely expressed in brain and other tissues, and is capable of hydrolyzing anandamide (AEA) and other simple esters and amides with long unsaturated acyl chains.1 JP104 is an irreversible fatty acid amide hydrolase (FAAH) inhibitor of the carbamate class with an IC50 of 7.3 nM for the human recombinant enzyme when tested using radiolabeled oleamide as the substrate.2 The alkyl derivative on JP104 reacts with azide-modified reporter tags, such as azido-rhodamine or azido-biotin, for visualization of JP104 bound to FAAH in vivo. |
| 别名 | Click Tag™ JP104; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Zhang, Y.H.,Zhang, G.Y.,Mollat, P., et al. Purification, characterization, and cellular localization of the 100-kDa human placental GTPase-activating protein. The Journal of Biological Chemisty 268, 18875-18881 (1993).
2.Alexander, J.P., and Cravatt, B.F. Mechanism of carbmate inactivation of FAAH: Implications for the design of covalent inhibitors and in vivo functional probes for enzymes. Chemistry & Biology 12, 1179-1187 (2005).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 406.5 |
| 分子式 | C25H30N2O3 |
| CAS号 | 887264-45-1 |
| 稳定性 | ≥ 2 years |
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