| 货号 | 15614-50mg |
| 描述 | CyPPA is a positive modulator of the small conductance calcium-activated potassium channels SK2 and SK3 (EC50s = 14 and 5.6 µM, respectively).1 It is inactive on both SK1 and the intermediate conductance calcium-activated potassium channel, IK.1,2 At SK3, CyPPA increases the apparent calcium-sensitivity of channel activation, changing the EC50 value of calcium activation from 429 to 59 nM.1 CyPPA is used to evaluate the roles of SK2 and SK3 in such diverse processes as memory encoding, uterine muscle contraction, and dopamine signaling.3,4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hougaard, C.,Eriksen, B.L.,Jorgensen, S., et al. Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channels. British Journal of Pharmacology 151(5), 655-665 (2007). 2.Hougaard, C.,Jensen, M.L.,Dale, T.J., et al. Selective activation of the SK1 subtype of human small-conductance Ca2+-activated K+ channels by 4-(2-methoxyphenylcarbamoyloxymethyl)-piperidine-1-carboxylic acid tert-butyl ester (GW542573X) is dependent on serine 293 in the S5 segment. Molecular Pharmacology 76(3), 569-578 (2009). 3.Vick, K.A.I.,Guidi, M. and Stackman, R.W., Jr. In vivo pharmacological manipulation of small conductance Ca2+-activated K+ channels influences motor behavior, object memory and fear conditioning. Neuropharmacology 58(3), 650-659 (2010). 4.Skarra, D.V.,Cornwell, T.,Solodushko, V., et al. CyPPA, a positive modulator of small-conductance Ca2+-activated K+ channels, inhibits phasic uterine contractions and delays preterm birth in mice. American Journal of Physiology.Cell Physiology 301(5), C1027-C1035 (2011). 5.Herrik, K.F.,Redrobe, J.P.,Holst, D., et al. CyPPA, a positive SK3/SK2 modulator, reduces activity of dopaminergic neurons, inhibits dopamine release, and counteracts hyperdopaminergic behaviors induced by methylphenidate. Front.Pharmacol. 3(11), (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 4 |
| 纯度 | ≥98% |
| 计算分子量 | 285.4 |
| 分子式 | C16H23N5 |
| CAS号 | 73029-73-9 |
| 稳定性 | ≥ 1 year |
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