| 货号 | 13657-50mg |
| 描述 | Clopidogrel is an antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC50 = 100 nM).1,2 Clopidogrel inhibits ADP-induced platelet aggregation ex vivo and functions as a prodrug whereupon biotransformation to its active metabolite via CYP2C19 in the liver enables its anti-aggregating activity.3 Marketed under the name Plavix®, clopidogrel in combination with aspirin has been shown to be beneficial in the prevention of vascular ischemic events for patients without deficiencies in CYP2C19-related metabolism.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Savi, P.,Labouret, C.,Delesque, N., et al. P2Y12, a new platelet ADP receptor, target of clopidogrel. Biochemical and Biophysical Research Communications 283, 379-383 (2001). 2.von Kügelgen, I. Pharmacological profiles of cloned mammalian P2Y-receptor subtypes. Pharmacology & Therapeutics 110, 415-432 (2006). 3.Quinn, M.J. and Fitzgerald, D.J. Ticlopidine and clopidogrel. Circulation Journal 100, 1667-1672 (1999). 4.Angiolillo, D.J.,Fernandez-Ortiz, A.,Bernardo, E., et al. Variability in individual responsiveness to clopidogrel: Clinical implications, management, and future perspectives. Journal of the American College of Cardiology 49(14), 1505-1516 (2007). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 358.3 |
| 分子式 | C16H16NO2S • HCl |
| CAS号 | 90055-48-4 |
| 稳定性 | ≥ 2 years |
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