| 货号 | 19619-50mg |
| 描述 | 7BIO is a derivative of indirubin (Item No. 14155) that triggers a rapid cell death process that is distinct from apoptosis and devoid of cytochrome c release or caspase activation.1 Furthermore, in contrast to other indirubin derivatives, 7BIO has only marginal activity against the classic indirubin targets, cyclin-dependent kinases and GSK3.1,2 Instead, 7BIO inhibits FLT3 (IC50 = 0.34 µM) and the dual-specificity tyrosine phosphorylation-regulated kinases, DYRK1A and DYRK2 (IC50s = 1.9 and 1.3 µM, respectively).1,3 It also inhibits Aurora B and C kinases with IC50 values of 4.6 and 0.7 µM, respectively.1,4 |
| 别名 | 7-Bromoindirubin-3’-oxime; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Ribas, J.,Bettayeb, K.,Ferandin, Y., et al. 7-Bromoindirubin-3-oxime induces caspase-independent cell death. Oncogene 25(47), 6304-6318 (2006). 2.Ferandin, Y.,Bettayeb, K.,Kritsanida, M., et al. 3-Substituted 7-halogenoindirubins, a new class of cell death inducing agents. Journal of Medicinal Chemistry 49, 4638-4649 (2006). 3.Myrianthopoulos, V.,Kritsanida, M.,Gaboriaud-Kolar, N., et al. Novel inverse binding mode of indirubin derivatives yields improved selectivity for DYRK kinases. ACS Med.Chem.Lett. 4(1), 22-26 (2013). 4.Myrianthopoulos, V.,Magiatis, P.,Ferandin, Y., et al. An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins. Journal of Medicinal Chemistry 50(17), 4027-4037 (2007). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% |
| 计算分子量 | 356.2 |
| 分子式 | C16H10BrN3O2 |
| CAS号 | 916440-85-2 |
| 稳定性 | ≥ 2 years |
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