| 货号 | 14747-10mg |
| 描述 | Cucurbitacin I is triterpenoid compound that acts as a potent inhibitor of the STAT3/JAK signaling pathway. It specifically suppresses levels of tyrosine phosphorylated STAT3 in v-Src-transformed NIH 3T3 cells and in A549 cells (IC50 = 500 nM) resulting in inhibition of STAT3 DNA binding and reduced STAT3-mediated gene transcription.1 It also suppresses JAK2 phosphorylation but does not affect Src, ERK, JNK or Akt.1 In nude mice, cucurbitacin I (1 mg/kg/day) suppressed growth of various tumors expressing constitutively active STAT3.1 It promotes the differentiation of dendritic cells and macrophages and enhances the effect of cancer immunotherapy.2 Cucubitacin I (1 µM for 2 hours) reduced clonogenicity of nasopharyngeal carcinoma cells in vitro and suppresses tumor growth in mice (1.3 mg/kg).3 |
| 别名 | Elatericin B;JSI-124;NSC 521777; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Blaskovich, M.A.,Sun, J.,Cantor, A., et al. Discovery of JSI-124 (Cucurbitacin I), a selective janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. Cancer Research 63(6), 1270-1279 (2003). 2.Nefedova, Y.,Nagaraj, S.,Rosenbauer, A., et al. Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacological selective inhibition of the Jak2/STAT3 pathway. Cancer Research 65(20), 9525-9535 (2005). 3.Lui, V.W.Y.,Yau, D.M.S.,Wong, E.Y.L., et al. Cucurbitacin I elicits anoikis sensitization, inhibits cellular invasion and in vivo tumor formation ability of nasopharyngeal carcinoma cells. Carcinogenesis 30(12), 2085-2094 (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 514.7 |
| 分子式 | C30H42O7 |
| CAS号 | 117793 |
| 稳定性 | ≥ 2 years |
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