| 货号 | 9000787-10mg |
| 描述 | Adenosine receptors are a family of G protein-coupled receptors that display distinct patterns of ligand binding and tissue distribution, regulating a variety of physiological functions. 2-chloro-3-Deazaadenosine is a stable analog of adenosine that acts as an agonist for adenosine receptors (Ki = 0.3, 0.08, 25.5, and 1.9 μM for A1, A2A, A2B, and A3 receptors, respectively).1,2 It can block neurotransmitter release by activating A1 receptors or inhibit neurotransmission by activating A2Areceptors.3,4,5 2-chloro-3-Deazaadenosine blocks seizures by stimulating A1receptors.6,7 |
| 别名 | 6-Amino-2-chloropurine riboside;2-CADO;NSC 158900; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Mathôt, R.A.A.,Soudijn, W.,Breimer, D.D., et al. Pharmacokinetic-haemodynamic relationships of 2-chloroadenosine at adenosine A1 and A2a receptors in vivo. British Journal of Pharmacology 118(2), 369-377 (1996). 2.Linden, J.,Thai, T.,Figler, H., et al. Characterization of human A2B adenosine receptors: Radioligand binding, western blotting, and coupling to Gq in human embryonic kidney 293 cells and HMC-1 mast cells. Molecular Pharmaceutics 56, 705-713 (1999). 3.Silinsky, E.M. On the mechanism by which adenosine receptor activation inhibits the release of acetylcholine from motor nerve endings. Journal of Physiology 346, 243-256 (1984). 4.Manzini, S., and Ballati, L. 2-Chloroadenosine induction of vagally-mediated and atropine-resistant bronchomotor responses in anaesthetized guinea-pigs. British Journal of Pharmacology 100(2), 251-256 (1990). 5.Pousinha, P.A.,Correia, A.M.,Sebastiao, A.M., et al. Predominance of adenosine excitatory over inhibitory effects on transmission at the neuromuscular junction of infant rats. Journal of Pharmacology and Experimental Therapeutics 332(1), 153-163 (2010). 6.Malhotra, J., and Gupta, Y.K. Effect of adenosine receptor modulation on pentylenetetrazole-induced seizures in rats. British Journal of Pharmacology 120(2), 282-288 (1997). 7.Ates, N.,Ilbay, G., and Sahin, D. Suppression of generalized seizures activity by intrathalamic 2-chloroadenosine application. Experimental Biology and Medicine 230(7), 501-505 (2005). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 300.7 |
| 分子式 | C11H13ClN4O4 |
| CAS号 | 40656-71-1 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |