1,25-dihydroxy Vitamin D2
货号：
11174-5mg 基本售价：
6944.0 元 规格：
5 mg
产品信息
概述| 货号 | 11174-5mg |
| 描述 | 1,25-dihydroxy Vitamin D2 is the active circulating metabolite of vitamin D2 formed by 25-hydroxylase in the liver and 25-hydroxyvitamin D-hydroxylase in the kidney.1 By binding to the vitamin D receptor (VDR), 1,25-dihydroxy Vitamin D2 activates VDR to interact with the retinoid X receptor (RXR), forming the VDR/RXR/cofactor complex, which regulates gene transcription.2 Because 1,25-dihydroxy Vitamin D2 circulates at picomolar concentrations and is highly lipophilic, it is difficult to quantify.1 |
| 别名 | Ercalcitriol;Ro 17-6218; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sudsakorn, S.,Phatarphekar, A.,OShea, T., et al. Determination of 1,25-dihydroxyvitamin D2 in rat serum using liquid chromatography with tandem mass spectrometry. Journal of Chromatography B 879, 139-145 (2011).
2.Kato, S.,Kim, M.S.,Yamaoka, K., et al. Mechanisms of transcriptional repression by 1,25(OH)2 vitamin D. Current Opinion in Nephrology and Hypertension 16, 297-304 (2007).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 428.7 |
| 分子式 | C28H44O3 |
| CAS号 | 60133-18-8 |
| 稳定性 | ≥ 2 years |
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