| 货号 | 10878-100ug |
| 描述 | Docosahexaenoic acid (DHA; Item No. 90310) is an ω-3 fatty acid that is abundant in the brain and the retina and is known to be important in early development.1,2 Maresin 1 (7(R)-MaR1) is a 7,14-dihydroxy DHA formed from 14(S)-hydroperoxy DHA supplied exogenously to resident peritoneal mouse macrophages activated with zymosan A. It potently reduces infiltration of neutrophils into the mouse peritoneum in zymosan A-induced peritonitis when given intravenously (0.2 ng) and significantly increases phagocytosis of FITC-labeled zymosan A by isolated mouse macrophages (0.1-100 nM).3 Analytical and biological comparisons of synthetic 7(R)-MaR1 with endogenously derived 7(R)-MaR1 have confirmed its identity as matching the natural product.4 |
| 别名 | 7(R)-MaR1;7(R)-Maresin 1; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Su, H.M. Mechanisms of n-3 fatty acid-mediated development and maintenance of learning memory performance. Journal of Nutritional Biochemistry 21, 364-373 (2010). 2.Wu, T.C. and Chen, P.H. Health consequences of nutrition in childhood and early infancy. Pediatrics and Neonatology 50(4), 135-142 (2009). 3.Serhan, C.N.,Yang, R.,Martinod, K., et al. Maresins: Novel macrophage mediators with potent antiinflammatory and proresolving actions. Journal of Experimental Medicine 206, 15-23 (2009). 4.Serhan, C. . (2007). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥95% |
| 计算分子量 | 360.5 |
| 分子式 | C22H32O4 |
| CAS号 | 1268720-28-0 |
| 稳定性 | ≥ 1 year |
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