| 货号 | 10794-5mg |
| 描述 | Agonists of the vitamin D receptor are used to suppress parathyroid hormone (PTH) synthesis and secretion in the treatment of hyperparathyroidism associated with renal failure.1 22-Oxacalcitriol is an analog of calcitriol that, like calcitriol, is a receptor-active form of vitamin D3 which effectively blocks PTH synthesis.2,3 First reported to avoid hypercalcemia, an undesirable side effect of calcitriol, prolonged treatment with 22-oxalcalcitriol can be calcemic in humans.2,3 Analogs of calcitriol, including 22-oxacalcitriol, inhibit human keratinocyte proliferation while inducing differentiation and is beneficial in treating psoriasis.4,5 22-Oxacalcitriol also blocks the proliferation while inducing differentiation and apoptosis of certain tumor cells.6 |
| 别名 | Maxacalcitrol; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Brown, A.J.,Dusso, A.S. and Slatopolsky, E. Vitamin D analogues for secondary hyperparathyroidism. Nephrology Dialysis Transplantation 17, 10-19 (2002). 2.Brown, A.J.,Ritter, C.R.,Finch, J.L., et al. The noncalcemic analogue of vitamin D, 22-oxacalcitriol, suppresses parathyroid hormone synthesis and secretion. Journal of Clinical Investigation 84, 728-732 (1989). 3.Akizawa, T.,Suzuki, M.,Akiba, T., et al. Long-term effect of 1,25-dihydroxy-22-oxavitamin D3 on secondary hyperparathyroidism in haemodialysis patients. One-year administration study. Nephrology Dialysis Transplantation 17, 28-36 (2002). 4.Takahashi, H.,Ibe, M.,Kinouchi, M., et al. Similarly potent action of 1,25-dihydroxyvitamin D3 and its analogues, tacalcitol, calcipotriol, and maxacalcitol on normal human keratinocyte proliferation and differentiation. Journal of Dermatological Science 31(1), 21-28 (2003). 5.Okubo, Y.,Natsume, S.,Usui, K., et al. Combination therapy using maxacalcitol and corticosteroid lotions preliminary to monotherapy with maxacalcitol lotion for scalp psoriasis. J.Dermatolog.Treat. (2012). 6.Seubwai, W.,Wongkham, C.,Puapairoj, A., et al. 22-Oxa-1,25-dihydroxyvitamin D3 efficiently inhibits tumor growth in inoculated mice and primary histoculture of cholangiocarcinoma. Cancer 116(23), 5535-5543 (2010). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 418.6 |
| 分子式 | C26H42O4 |
| CAS号 | 103909-75-7 |
| 稳定性 | ≥ 2 years |
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