| 货号 | 19874-5g |
| 描述 | Tetrandrine is a natural, bis-benzylisoquinoline alkaloid first isolated from the root of the plant R. stephania tetrandrae.1 It acts a calcium channel blocker (IC50s = 8 and 20 µM for L-type and T-type calcium channels, respectively) and induces apoptosis, which produces anti-inflammatory, immunomodulating, anti-proliferative, and free radical scavenging effects.1,2,3 Tetrandrine has also been shown to increase glucose utilization by enhancing hepatocyte glycogen synthesis.4 |
| 别名 | Fanchinine;NSC 77037;Sinomenine A;d-tetrandrine;(S,S)-(+)-tetrandrine;TTD; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Wie, Q.-M.,Tang, H.-F.,Chen, J.-Q., et al. Pharmacological actions of tetrandrine in inflammatory pulmonary diseases. Acta. Pharmacol. Sin. 23(12), 1107-1113 (2002). 2.Yang, Z.,Concannon, J.,Ng, K.S., et al. Tetrandrine identified in a small molecule screen to activate mesenchymal stem cells for enhanced immunomodulation. Sci. Rep. 6:30263, (2016). 3.Wang, H.,Liu, T.,Li, L., et al. Tetrandrine is a potent cell autophagy agonist via activated intracellular reactive oxygen species. Cell Biosci. 5:4, (2015). 4.Hsu, J.-H.,Wu, Y.-C.,Liou, S.-S., et al. Mediation of endogenous β-endorphin by tetrandrine to lower plasma glucose in streptozotocin-induced diabetic rats. Evid Based Complement. Med. 1(2), 193-201 (2004). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 622.8 |
| 分子式 | C38H42N2O6 |
| CAS号 | 518-34-3 |
| 稳定性 | ≥ 2 years |
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