MMP-13 Inhibitor
货号：
19540-10mg 基本售价：
6930.0 元 规格：
10 mg
产品信息
概述| 货号 | 19540-10mg |
| 描述 | MMP-13 Inhibitor is a pyrimidine dicarboxamide that inhibits matrix metalloproteinase-13 (MMP-13, also known as collagenase-3) with an IC50 value of 8 nM.1,2 MMP-13 Inhibitor binds to pockets that are unique to MMP-13, rather than the catalytic zinc, and thus is specific for MMP-13 over other MMPs.1,2 MMP-13 Inhibitor blocks osterix-dependent calcification of matrices in limb bud cells during endochondral ossification.3 |
| 别名 | Collagenase-3 Inhibitor;Matrix Metalloproteinase-13 Inhibitor;4,6-Pyrimidinedicarboxamide; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Carrascal, N.A., and Rizzo, R.C. Calculation of binding free energies for non-zinc chelating pyrimidine dicarboxamide inhibitors with MMP-13. Bioorg.Med.Chem.Lett. 19(1), (2009).
2.Engel, C.K.,Pirard, B.,Schimanski, S., et al. Structural basis for the highly selective inhibition of MMP-13. Chem.Biol. 12(2), 181-189 (2005).
3.Nishimura, R.,Wakabayashi, M.,Hata, K., et al. Osterix regulates calcification and degradation of chondrogenic matrices through matrix metalloproteinase 13 (MMP13) expression in association with transcription factor Runx2 during endochondral ossification. J.Biol.Chem. 287(40), 33179-33190 (2012).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 410.4 |
| 分子式 | C22H20F2N4O2 |
| CAS号 | 544678-85-5 |
| 稳定性 | ≥ 2 years |
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