Cdk5 Substrate
货号：
17477-10mg 基本售价：
6930.0 元 规格：
10 mg
产品信息
概述| 货号 | 17477-10mg |
| 描述 | Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine kinase that is predominantly active in neuronal tissues. With p25 or p35, Cdk5 phosphorylates a range of proteins, including histone H1 and tau.1 Cdk5 substrate is a synthetic peptide (PKTPKKAKKL) corresponding to a sequence of histone H1. It is phosphorylated by Cdk5 with a Km value of 5 µM.2,3 |
| 别名 | Cyclin-dependent kinase 5 Substrate; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Peterson, D.W.,Ando, D.M.,Taketa, D.A., et al. No difference in kinetics of tau or histone phosphorylation by CDK5/p25 versus CDK5/p35 in vitro. Proceedings of the National Academy of Sciences of the United States of America 107(7), 2884-2889 (2010).
2.Beaudette, K.N.,Lew, J., and Wang, J.H. Substrate specificity characterization of a cdc2-like protein kinase purified from bovine brain. The Journal of Biological Chemisty 268(28), 20825-20830 (1993).
3.Sharma, P.,Steinbach, P.J.,Sharma, M., et al. Identification of substrate binding site of cyclin-dependent kinase 5. The Journal of Biological Chemisty 274(14), 9600-9606 (1999).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 1138.5 |
| 分子式 | C53H99N15O12 |
| CAS号 | 164669-07-2 |
| 稳定性 | ≥ 2 years |
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