SET7/9 (human recombinant)
货号：
10320-500ug 基本售价：
6930.0 元 规格：
500 ug
产品信息
概述| 货号 | 10320-500ug |
| 描述 | Methylation of lysine can promote transcriptional activation or repression and is critical in regulating histone function.1 Lysine residues can be mono-, di-, or tri-methylated, and unlike most SET proteins, SET7/9 is exclusively a mono-methylase.2 SET7/9 methylates histone H3, tumor suppressor p53, and transcription factor TAF10.3 Recently, SET7/9 was shown to catalyze methylation of p53 in response to DNA damage thereby activating p53 for subsequent acetylation.1 SET7/9 is able to modulate p53 activity in a human cancer cell line, implying that it may play a significant role in human tumorigenesis. |
| 别名 | KMT7;SETD7;SETD7/9;SET Domain-containing Protein 7/9; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kurash, J.K.,Lei, H.,Shen, Q., et al. Methylation of p53 by Set7/9 mediates p53 acetylation and activity in vivo. Molecular Cell 29, 392-400 (2008).
2.Xiao, B.,Jing, C.,Wilson, J.R., et al. Structure and catalytic mechanism of the human histone methyltransferase SET7/9. Nature 421, 652-656 (2003).
3.Couture, J.F.,Collazo, E.,Hauk, G., et al. Structural basis for the methylation site specificity of SET7/9. Nature Structural & Molecular Biology 13(2), 140-146 (2006).
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| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥95% estimated by SDS-PAGE |
| 稳定性 | ≥ 6 months |
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