24(S)-hydroxy Cholesterol
货号：
10009931-10mg 基本售价：
6930.0 元 规格：
10 mg
产品信息
概述| 货号 | 10009931-10mg |
| 描述 | 24(S)-hydroxy Cholesterol is a side-chain substituted oxysterol that has important roles in cholesterol homeostasis. It is generated by the action of CYP46 on cholesterol in the brain and diffuses across the blood-brain barrier to the systemic circulation where it can modulate cell signaling, be used for further sterol biosynthesis, or be metabolized in the liver.1 24(S)-hydroxy cholesterol potently activates LXRα and LXRβ nuclear receptors (EC50 = 4 and 3 μM, respectively), causing upregulation of cholesterol-lowering genes.1,2,3 In the brain, this oxysterol controls cholesterol processing to facilitate neurological repair during Alzheimer’s disease and other neuropathological conditions.1 |
| 别名 | Cerebrosterol; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Vaya, J., and Schipper, H.M. Oxysterols, cholesterol homeostasis, and Alzheimer disease. Journal of Neurochemistry 102, 1727-1737 (2007).
2.Janowski, B.A.,Grogan, M.J.,Jones, S.A., et al. Structural requirements of ligands for the oxysterol liver X receptors LXRα and LXRβ. Proceedings of the National Academy of Sciences of the United States of America 96(1), 266-271 (1999).
3.Geyeregger, R.,Zeyda, M., and Stulnig, T.M. Liver X receptors in cardiovascular and metabolic disease. Cellular and Molecular Life Sciences 63, 524-539 (2006).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 402.7 |
| 分子式 | C27H46O2 |
| CAS号 | 474-73-7 |
| 稳定性 | ≥ 2 years |
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