ZLN024
货号：
21644-50mg 基本售价：
6860.0 元 规格：
50 mg
产品信息
概述| 货号 | 21644-50mg |
| 描述 | ZLN024 is an allosteric activator of AMP-activated protein kinase (AMPK) heterotrimers (EC50s = 0.42 and 0.95 µM for α1β1γ1 and α2β1γ1, respectively).1 Activation of AMPK by ZLN024 requires phosphorylation of AMPK on Thr172, and ZLN024 protects Thr172 from dephosphorylation by protein phosphatase 2Cα.1 ZLN024 stimulates glucose uptake and fatty acid oxidation in L6 myotubes. In primary hepatocytes, ZLN024 decreases fatty acid synthesis and glucose output.1 ZLN024 reduces liver triacylglycerol and total cholesterol content and improves glucose tolerance in db/dbmice.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Zhang, L.-N.,Xu, L.,Zhou, H.-Y., et al. Novel small-molecule AMP-activated protein kinase allosteric activator with beneficial effects in db/db mice.. PLoS One 8(8), e72092 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 325.2 |
| 分子式 | C13H13BrN2OS |
| CAS号 | 723249-01-2 |
| 稳定性 | ≥ 2 years |
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