GDC-0980
货号：
18303-25mg 基本售价：
6860.0 元 规格：
25 mg
产品信息
概述| 货号 | 18303-25mg |
| 描述 | GDC-0980 is a potent inhibitor of class I phosphatidylinositol 3-kinase (PI3K) isoforms, with IC50 values of 5, 27, 7, and 14 nM for PI3Kα, β, δ, and γ, respectively, in cell-free assays.1,2 It also inhibits mTOR (Ki = 17 nM) but is inactive against a large panel of additional kinases.1,2 GDC-0980 induces cell cycle arrest or apoptosis in a range of cancer cell lines.2 It is effective in vivo, suppressing the growth of a number of tumor xenografts in mice and enhancing the antitumor activity of docetaxel (Item No. 11637) in mice.2 |
| 别名 | Apitolisib;RG7422; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sutherlin, D.P.,Bao, L.,Berry, M., et al. Discovery of a potent, selective, and orally available class I phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) kinase inhibitor (GDC-0980) for the treatment of cancer. Journal of Medicinal Chemistry 54(21), 7579-7587 (2011).
2.Wallin, J.J.,Edgar, K.A.,Guan, J., et al. GDC-0980 is a novel class I PI3K/mTOR kinase inhibitor with robust activity in cancer models driven by the PI3K pathway. Molecular Cancer Therapeutics 10(12), 2426-2436 (2011).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 498.6 |
| 分子式 | C23H30N8O3S |
| CAS号 | 1032754-93-0 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
