FLI-06
货号：
21272-50mg 基本售价：
6832.0 元 规格：
50 mg
产品信息
概述| 货号 | 21272-50mg |
| 描述 | FLI-06 is a first-of-its-kind inhibitor of Notch signaling (EC50 = 2.3 µM) that acts upstream of α-secretase and β-secretase cleavage.1 It disrupts the intracellular trafficking and processing of the Notch signaling pathway, inhibiting general secretion at a stage before exit from the endoplasmic reticulum (ER) and converting ER morphology from tubule to sheet.1 FLI-06 is reported to alter the maturation pattern of amyloid precursor protein (APP) and prevent the shedding of APPs in HEK293 cells stably expressing a mutated APP that yields robust amounts of amyloid β.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Krämer, A.,Mentrup, T.,Kleizen, B., et al. Small molecules intercept Notch signaling and the early secretory pathway. Nat. Chem. Biol. 9(11), 731-738 (2013).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 438.5 |
| 分子式 | C25H30N2O5 |
| CAS号 | 313967-18-9 |
| 稳定性 | ≥ 2 years |
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