| 货号 | 19710-25mg |
| 描述 | Tpl2 kinase inhibitor is a reversible inhibitor of tumor progression locus 2 (Tpl2; pIC50 = 7.3).1 It blocks LPS-induced TNF-α production in mice and human monocytes.1,2 Tpl2 kinase inhibitor has been used to evaluate the role of this enzyme in the proliferation and differentiation of cancer cells.3,4 |
| 别名 | c-Cot Kinase Inhibitor;MAP3K8 Kinase Inhibitor;Tumor Progression Locus 2 Kinase Inhibitor; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Garvin, L.K.,Green, N.,Hu, Y., et al. Inhibition of Tpl2 kinase and TNF-α production with 1,7-naphthyridine-3-carbonitriles: Synthesis and structure-activity relationships. Bioor. Med. Chem. Lett. 15(23), 5288-5292 (2005). 2.Hu, Y.,Green, N.,Gavrin, L.K., et al. Inhibition of Tpl2 kinase and TNFα production with quinoline-3-carbonitriles for the treatment of rheumatoid arthritis. Bioor. Med. Chem. Lett. 16(23), 6067-6072 (2006). 3.Wang, X.,Gocek, E.,Novik, V., et al. Inhibition of Cot1/Tlp2 oncogene in AML cells reduces ERK5 activation and up-regulates p27Kip1 concomitant with enhancement of differentiation and cell cycle arrest induced by silibinin and 1,25-dihydroxyvitamin D3. Cell Cycle 9(22), 4542-4551 (2010). 4.Wang, X. and Studzinski, G.P. Expression of MAP3 kinase COT1 is up-regulated by 1,25-dihydroxyvitamin D3 in parallel with activated c-jun during differentiation of human myeloid leukemia cells. J. Steroid. Biochem. Mol. Biol. 121(1-2), 395-398 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 404.8 |
| 分子式 | C21H14ClFN6 |
| CAS号 | 871307-18-5 |
| 稳定性 | ≥ 2 years |
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