6H05 (trifluoroacetate salt)
货号：
17985-25mg 基本售价：
6832.0 元 规格：
25 mg
产品信息
概述| 货号 | 17985-25mg |
| 描述 | The Ras family of small GTPases (H-Ras, K-Ras, and N-Ras) function as molecular switches, cycling between a GTP-bound active state and a GDP-bound inactive state, to turn on downstream Raf protein kinases. This initiates complex signaling pathways involved in cell growth, differentiation, and apoptosis. Mutations leading to aberrant Ras activation are frequently associated with various human cancers. 6H05 is a small molecule that allosterically binds to a mutant cysteine on oncogenic K-Ras(G12C), thus inhibiting its function.1 Binding of 6H05 to K-Ras(G12C) disrupts both switch-I and switch-II, altering the native nucleotide preference to favor GDP over GTP, which impedes binding to Raf.1 Because 6H05 is selective for mutant Cys-12, it does not affect wild-type K-Ras.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ostrem, J.M.,Peters, U.,Sos, M.L., et al. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature 503(7477), 548-551 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 590.1 |
| 分子式 | C20H30ClN3O2S3 • CF3COOH |
| 稳定性 | ≥ 2 years |
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