6-OAU
货号：
17687-10mg 基本售价：
6832.0 元 规格：
10 mg
产品信息
概述| 货号 | 17687-10mg |
| 描述 | GPR84 is a Gαi protein-coupled receptor that is activated by medium-chain free fatty acids, but only at micromolar concentrations.1 GPR84 is expressed in leukocytes and its expression is further induced by LPS.1,2 6-OAU is a synthetic agonist for GPR84 (EC50 = 512 nM).2 It has insignificant actions at a panel of 69 other receptors, channels, or transporters.2 6-OAU promotes chemotaxis in human neutrophils (EC50 = 318 nM) and amplifies TNF-α production by LPS-treated U937 macrophages.2 In rats, 6-OAU (1 mg/ml) drives the recruitment of neutrophils and macrophages when injected into a subcutaneous air pouch and raises serum levels of CXCL1 (growth-regulated α protein) when delivered intravenously.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Davenport, A.P.,Alexander, S.P.H.,Sharman, J.L., et al. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: Recommendations for new pairings with cognate ligands. Pharmacological Reviews 65(3), 967-986 (2013).
2.Suzuki, M.,Takaishi, S.,Nagasaki, M., et al. Medium-chain fatty acid-sensing receptor, GPR84, is a proinflammatory receptor. The Journal of Biological Chemisty 288(15), 10684-10691 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 239.3 |
| 分子式 | C12H21N3O2 |
| CAS号 | 83797-69-7 |
| 稳定性 | ≥ 2 years |
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