| 货号 | 16985-5mg |
| 描述 | Rp-Cyclic AMPS (Rp-cAMPS) is a non-hydrolyzable phosphorothioate analog of cAMP.1 It is a competitive inhibitor of cAMP-dependent protein kinases I and II (IC50s = 12.5 and 4.5 µM, respectively).2,3 Rp-cAMPS is not hydrolyzed by bovine heart cAMP phosphodiesterase but can be hydrolyzed by yeast phosphodiesterase.4 It is broadly used in research involving cAMP-dependent signaling in vitroandin vivo.1,5,6 |
| 别名 | Rp-cAMPS; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Schaap, P.,van Ments-Cohen, M.,Soede, R.D., et al. Cell-permeable non-hydrolyzable cAMP derivatives as tools for analysis of signaling pathways controlling gene regulation in Dictyostelium. The Journal of Biological Chemisty 268(9), 6323-6331 (1993). 2.De Wit, R.J.W.,Hekstra, D.,Jastorff, B., et al. Inhibitory action of certain cyclophosphate derivatives of cAMP on cAMP-dependent protein kinases. European Journal of Biochemistry 142(2), 255-260 (1984). 3.Van Haastert, P.J.M.,van Driel, R.,Jastorff, B., et al. Competitive cAMP antagonists for cAMP-receptor proteins. The Journal of Biological Chemisty 259(16), 10020-10024 (1984). 4.Jarvest, R.L.,Lowe, G.,Baraniak, J., et al. A stereochemical investigation of the hydrolysis of cyclic AMP and the (Sp)-and (Rp)-diastereoisomers of adenosine cyclic 3:5-phosphorothioate by bovine heart and baker’s-yeast cyclic AMP phosphodiesterases. Biochemistry Journal 203(2), 461-470 (1982). 5.Schwede, F.,Maronde, F.,Genieser, H., et al. Cyclic nucleotide analogs as biochemical tools and prospective drugs. Pharmacology & Therapeutics 87(2), 199-226 (2000). 6.Yokozaki, H.,Tortora, G.,Pepe, S., et al. Unhydrolyzable analogues of adenosine 3:5-monophosphate demonstrating growth inhibition and differentiation in human cancer cells. Cancer Research 52(9), 2504-2508 (1992). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 446.5 |
| 分子式 | C10H11N5O5PS • C6H16N |
| CAS号 | 151837-09-1 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |