| 货号 | 16721-5mg |
| 描述 | Senktide is a potent, selective agonist of the neuromedin K3 (NK3) receptor (EC50 = 0.5-3 nM).1,2,3 It less potently agonizes the NK1 receptor (EC50 = 35 µM) and is without effect on the NK2receptor.1,2,3 Senktide is used to study the action of the NK3 receptor in cells and in animals.4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Byk, G.,Halle, D.,Zeltser, I., et al. Synthesis and biological activity of NK-1 selective, N-backbone cyclic analogs of the C-terminal hexapeptide of substance P. J.Med.Chem 39(16), 3174-3178 (1996). 2.Sarau, H.M.,Griswold, D.E.,Potts, W., et al. Nonpeptide tachykinin receptor antagonists: I. Pharmacological and pharmacokinetic characterization of SB 223412, a novel, potent and selective neurokinin-3 receptor antagonist. Journal of Pharmacology and Experimental Therapeutics 281(3), 1303-1311 (1997). 3.Harrison, T.,Korsgaard, M.P.,Swain, C.J., et al. High affinity, selective neurokinin 2 and neurokinin 3 receptor antagonists from a common structural template. Bioorganic & Medicinal Chemistry Letters 2, 1343-1348 (1998). 4.Thakar, A.,Sylar, E. and Flynn, F.W. Activation of tachykinin, neurokinin 3 receptors affects chromatin structure and gene expression by means of histone acetylation. Peptides 38(2), 282-290 (2012). 5.Gaskins, G.T.,Glanowska, K.M. and Moenter, S.M. Activation of neurokinin 3 receptors stimulates GnRH release in a location-dependent but kisspeptin-independent manner in adult mice. Endocrinology 154(11), 3984-3989 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 842 |
| 分子式 | C40H55N7O11S |
| CAS号 | 106128-89-6 |
| 稳定性 | ≥ 2 years |
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