| 货号 | 14424-100mg |
| 描述 | Darifenacin is a receptor antagonist acting at the muscarinic receptors (Ki = 5.5, 47, 0.84, 8.6, and 2.3 nM for M1 through M5, respectively).1,2 It is effective in treating problems related to the lower urinary tract, including incontinence and overactive bladder.3,4 |
| 别名 | UK 88525-04; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Bockman, C.S.,Bradley, M.E.,Dang, H.K., et al. Molecular and pharmacological characterization of muscarinic receptor subtypes in a rat parotid gland cell line: Comparison with native parotid gland. Journal of Pharmacology and Experimental Therapeutics 297(2), 718-726 (2001). 2.Sagara, Y.,Sagara, T.,Mase, T., et al. Cyclohexylmethylpiperidinyltriphenylpropioamide: A selective muscarinic M3 antagonist discriminating agaisnt the other receptor subtypes. Journal of Medicinal Chemistry 45(4), 984-987 (2002). 3.Yamada, S.,Ito, Y. and Tsukada, H. α1-Adrenoceptors and muscarinic receptors in voiding function - binding characteristics of therapeutic agents in relation to the pharmacokinetics. British Journal of Clinical Pharmacology 72(2), 205-217 (2011). 4.Lam, S. and Hilas, O. Pharmacologic management of overactive bladder. Clinical Interventions in Aging 2(3), 337-345 (2007). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 507.5 |
| 分子式 | C28H30N2O2 • HBr |
| CAS号 | 133099-07-7 |
| 稳定性 | ≥ 2 years |
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