| 货号 | 13514-10mg |
| 描述 | K252c is a cell-permeable PKC inhibitor (IC50s = 2.45 and 25.7 µM for PKC and PKA, respectively).1 It induces apoptosis in human chronic myelogenous leukemia cancer cells.2 In human foreskin fibroblast cells, it reduces focus formation induced by human cytomegalovirus (HCMV) strains sensitive and resistant to Ganciclovir (Item No. 13853) with IC50s of 0.32 and 0.17 µM for HCMV A6245 and HCMV-6, respectively.3 It also inhibits the non-kinase enzymes β-lactamase, chymotrypsin, and malate dehydrogenase with IC50s of 8, 10, and 8 µM, suggesting less kinase-selectivity than was originally described.4 |
| 别名 | SD 1825;Staurosporine aglycone; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Pereira, E.R.,Belin, L.,Sancelme, M., et al. Structure-activity relationships in a series of substituted indolocarbazoles: Topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties. J. Med. Chem. 39(22), 4471-4477 (1996). 2.Liu, R.,Zhu, T.,Li, D., et al. Two indolocarbazole alkaloids with apoptosis activity from a marine-derived actinomycete Z2039-2. Arch. Pharm. Res. 30(3), 270-274 (2007). 3.Zimmermann, A.,Wilts, H.,Lenhardt, M., et al. Indolocarbazoles exhibit strong antiviral activity against human cytomegalovirus and are potent inhibitors of the pUL97 protein kinase. Antiviral Res. 48(1), 49-60 (2000). 4.McGovern, S.L. and Shoichet, B.K. Kinase inhibitors: Not just for kinases anymore. Journal of Medicinal Chemistry 46, 1478-1483 (2003). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 311.3 |
| 分子式 | C20H13N3O |
| CAS号 | 85753-43-1 |
| 稳定性 | ≥ 2 years |
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