AL 8810 ethyl amide
货号：
10010470-10mg 基本售价：
6832.0 元 规格：
10 mg
产品信息
概述| 货号 | 10010470-10mg |
| 描述 | AL 8810 is an 11β-fluoro analog of prostaglandin F2α(PGF2α) which acts as a potent and selective antagonist at the FP receptor.1 AL 8810 ethyl amide is an analog of AL 8810 in which the C-1 carboxyl group has been modified to an N-ethyl amide. This modification is analogous to the PG N-ethyl amides, as typified by Bimatoprost, that have been introduced as alternative PG ocular hypotensive prodrugs.2 In contrast to AL 8810 which contracted the cat iris, AL 8810 ethyl amide showed no contraction activity at concentrations up to 10-4 M and did not antagonize the activity of PGF2α-ethanolamide in this system.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Griffen, B.W.,Klimko, P.,Crider, J.Y., et al. AL-8810: A novel prostaglandin F2α analog with selective antagonist effects at the prostaglandin F2α (FP) receptor. Journal of Pharmacology and Experimental Therapeutics 290(3), 1278-1284 (1999).
2.Woodward, D.F.,Krauss, A.H.P.,Chen, J., et al. The pharmacology of Bimatoprost (Lumigan™). Survey of Ophthalmology 45, S337-S345 (2001).
3.Woodward, D.F.,Krauss, A.H.,Wang, J.W., et al. Identification of an antagonist that selectively blocks the activity of prostamides (prostaglandin-ethanolamides) in the feline iris. British Journal of Pharmacology 150, 342-352 (2007).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 429.6 |
| 分子式 | C26H36FNO3 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
