N-Octadecyl-N-propyl-sulfamide
货号：
10009661-50mg 基本售价：
6832.0 元 规格：
50 mg
产品信息
概述| 货号 | 10009661-50mg |
| 描述 | Peroxisome proliferator-activated receptors (PPARs) play an essential role in regulating lipid and glucose metabolism. Oleoyl ethanolamide (OEA), a natural ligand for PPARα, has been shown to suppress food intake and reduce weight gain in rats when administered systemically at 10 mg/kg intraperitoneally.1,2 N-Octadecyl-N-propyl-sulfamide is an analog of OEA with selective binding affinity for PPARα. It is a more potent activator of PPARα, exhibiting an EC50 value of 100 nM, compared to OEA, which exhibits an EC50 value of 120 nM.3,2 At a dose of 1 mg/kg for 8-11 days, N-octadecyl-N-propyl-sulfamide induces satiety, thereby decreasing food-intake, body weight, and plasma triglyceride concentration in free-feeding Wistar and obese Zucker (fa/fa) rats.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.de Fonseca, F.R.,Navarro, M.,Gómez, R., et al. An anorexic lipid mediator regulated by feeding. Nature 414, 209-212 (2001).
2.Fu, J.,Gaetani, S.,Oveisi, F., et al. Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-α. Nature 425, 90-93 (2003).
3.Cano, C.,Pavón, J.,Serrano, A., et al. Novel sulfamide analogs of oleoylethanolamide showing in vivo satiety inducing actions and PPARα activation. Journal of Medicinal Chemistry 50, 389-393 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 390.7 |
| 分子式 | C21H46N2O2S |
| CAS号 | 925891-74-3 |
| 稳定性 | ≥ 2 years |
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