| 货号 | 1568/25 |
| 别名 | N-[2-(3,4-Dihydroxyphenyl)ethyl]-5Z |
| 供应商 | Tocris |
| 生物活性 | Potent endogenous cannabinoid and vanilloid receptor agonist, with no action at dopamine receptors. Selective for CB1 over CB2 receptors (Ki values are 0.25 and 12 μM respectively), and potent agonist at TRPV1 (VR1) receptors (EC50 ~ 50 nM). Metabolically stable and competitively inhibits FAAH and anandamide transport. Has cannabinoid and vanilloid actions in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 439.64 |
| 分子式 | C28H41NO3 |
| 可溶性/溶解性 | Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml) |
| 参考文献 | Huanget al (2002) An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors. Proc.Natl.Acad.Sci.U.S.A. 99 8400. PMID: 12060783. Bisognoet al(2000)N-acyl-dopamines: novel synthetic CB1 cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitroandin vivo. Biochem.J. 351 817. PMID: 11042139. De Petrocelliset al (2000) Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: inhibitors of anandamide uptake with negligible capsaicin-like activity. FEBS Lett. 483 52. PMID: 11033355. |