| 货号 | 1256/50 |
| 别名 | Vincaleukoblastine |
| 供应商 | Tocris |
| 生物活性 | Anticancer agent; microtubule disrupter. Induces apoptosis in cultured hepatocytes and human lymphoma cells. Shown to inhibit autophagosome maturation. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >95 % |
| 计算分子量 | 909.06 |
| 分子式 | C46H58N4O9.H2SO4 |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 100 mM in DMSO |
| CAS号 | 143-67-9 |
| 参考文献 | Veldhoenet al (2012) The chemotherapeutic agent paclitaxel inhibits autophagy through two distinct mechanisms that regulate apoptosis. Oncogene 32 736. PMID: 22430212. Rai and Wolf (1998) Localization of critical histidyl residues required for vinblastine-induced tubulin polymerization and for microtubulin assembly. J.Biol.Chem. 273 31131. PMID: 9813016. Tsukidateet al (1993) Microtubule antagonists activate programmed cell death (apoptosis) in cultured rat hepatocytes. Am.J.Pathol. 143 918. PMID: 8362985. Jordanet al (1985) Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro. Cancer Res. 45 2741. PMID: 3986806. |