| 货号 | 2917/50 |
| 别名 | 1-[2-(Dimethylamino)-1-(4-methoxyph |
| 供应商 | Tocris |
| 生物活性 | Dual serotonin/noradrenalin re-uptake inhibitor that displays ~ 30-fold higher affinity for SERT than NET (Ki values are 82 and 2480 nM respectively). Antidepressant; increases swimming and climbing behavior in the forced-swim test in rats. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 313.86 |
| 分子式 | C17H27NO2.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 50 mM in DMSO |
| CAS号 | 99300-78-4 |
| 参考文献 | Gouldet al (2006) A comparison of the chronic treatment effects of venlafaxine and other antidepressants on serotonin and norepinephrine transporters. Biol.Psychiatry 59 408. PMID: 16140280. Magalaset al (2005) The serotonin/noradrenaline reuptake inhibitor venlafaxine attenuates acquistion, but not maintenance, of intravenous self-administration of heroin in rats. Eur.J.Pharmacol. 528 103. PMID: 16325805. Bymasteret al (2001) Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitroandin vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacol. 25871. |