| 货号 | 4297/50 |
| 别名 | 6-Bromo-N-2-propenyl-4-quinazolinam |
| 供应商 | Tocris |
| 生物活性 | Positive regulator of autophagy in a mechanism independent from the mTOR pathway. Increases autophagosome synthesis and enhances clearance of model autophagy substrates such as mutant huntingtin and A53T α-synuclein, associated with Huntington's and Parkinson's diseases, respectively. Promotes reprogramming of fibroblasts to neural stem-like cells in combination with other chemical reagents. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 264.12 |
| 分子式 | C11H10BrN3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Zhanget al (2016) Pharmacological reprogramming of fibroblasts into neural stem cells by signaling-directed transcriptional activation. Cell Stem Cell 18 653. PMID: 27133794. Rennaet al (2010) Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases. J.Biol.Chem. 285 11061. PMID: 20147746. Sarkaret al (2010) Small molecules enhance autophagy and reduce toxicity in Huntingtons disease models. Nat.Chem.Biol. 3 331. PMID: 17486044. |