| 货号 | 4598/50 |
| 别名 | 4-Dodecyl-N-1,3,4-thiadiazol-2-yl-b |
| 供应商 | Tocris |
| 生物活性 | Dual Akt and PDK1 inhibitor; binds the pleckstrin homology (PH) domain of Akt and PDK1 (Ki values are 2.7 and 5.2 μM, respectively). Inhibits Akt phosphorylation and Akt downstream targets; also induces apoptosis in vitro. Displays synergistic antitumor effect when combined with chemotherapeutics in breast cancer mouse models. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 409.61 |
| 分子式 | C20H31N3O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Meuilletet al (2010) Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor. Mol.Cancer Ther. 9 706. PMID: 20197390. Moseset al(2009)In vitroandin vivo activity of novel small-molecule inhibitors targeting the pleckstrin homology domain of protein kinase B/AKT. Cancer Res. 69 5073. PMID: 19491272. |