| 货号 | 2324/50 |
| 别名 | 5-(1H-Indol-3-ylmethyl)-3-methyl-2- |
| 供应商 | Tocris |
| 生物活性 | ATP-competitive, allosteric inhibitor of receptor-interacting protein kinase 1 (RIPK1) (EC50 = 182 nM). Blocks non-apoptotic cell death via inhibition of a specific cellular pathway, necroptosis, which leads to necrosis (EC50 = 494 nM). Reduces ischemic brain injury in a mouse model of stroke. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 259.33 |
| 分子式 | C13H13N3OS |
| 可溶性/溶解性 | Soluble to 30 mM in DMSO and to 15 mM in ethanol with gentle warming |
| CAS号 | 4311-88-0 |
| 参考文献 | Linkermannet al (2012) Rip1 (receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury. 81 751. PMID: 22237751. Degterevet al (2008) Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat.Chem.Biol. 4 313. PMID: 18408713. Degterevet al (2005) Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat.Chem.Biol. 1 112. PMID: 16408008. |