| 货号 | 3362/50 |
| 别名 | 1-[(1-Oxopropoxy)methyl]-1H-pyrrole |
| 供应商 | Tocris |
| 生物活性 | Restores wild-type conformation, function and DNA binding activity to mutant p53. Induces p53 transcriptional transactivation of p21, MDM2 and PUMA, and promotes tumor cell death by apoptosis in a mutant p53-dependent manner in vitro(IC50 = 10μM). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 计算分子量 | 183.16 |
| 分子式 | C8H9NO4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| CAS号 | 72835-26-8 |
| 参考文献 | Kumaret al (2007) p53 in breast cancer: mutation and countermeasures. Front.Biosci. 12 4168. PMID: 17485365. Wiman (2006) Strategies for therapeutic targeting of the p53 pathway in cancer. Cell Death Differ. 13 921. PMID: 16557267. Bykovet al (2005) Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs. J.Biol.Chem. 280 30384. PMID: 15998635. |