| 货号 | 1526/50 |
| 别名 | (2S)-2-Methyl-(1S,7S,8S,8aR)-1,2,3, |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of HMG-CoA reductase; decreases cholesterol biosynthesis, in vitroandin vivo. Induces apoptosis, arrests cancer cells in G1 phase and downregulates cdk 2, 4, and 6, cyclin D1 and E1, p21 and p27. Inactive lactam prodrug of mevastatin hydroxy acid, naturally bioactivated in vivo following oral administration. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 390.52 |
| 分子式 | C23H34O5 |
| 可溶性/溶解性 | Soluble to 25 mM in ethanol with gentle warming and to 50 mM in DMSO with gentle warming |
| CAS号 | 73573-88-3 |
| 参考文献 | Amin-Hanjaniet al (2001) Mevastatin, an HMG-CoA reductase inhibitor, reduces stroke damage and upregulates endothelial nitric oxide synthase in mice. Stroke 32 980. PMID: 11283400. Wachtershauseret al (2001) HMG-CoA reductase inhibitor mevastatin enhances the growth inhibitory effect of butyrate in the colorectal carcinoma cell line Caco-2. Carcinogenesis 22 1061. PMID: 11408350. Cohenet al (1984) Effects of compactin, mevalonate and low-density lipoprotein on 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity and low-density lipoprotein-receptor activity in the human hepatoma cell line Hep G2. Biochem.J. 222 35. PMID: 6089762. |