| 货号 | 4921/50 |
| 别名 | 4-[(5-[[4-Oxo-3-(phenylmethyl)-2-th |
| 供应商 | Tocris |
| 生物活性 | Allosteric activator of CD11b/CD18. Increases CD11b/CD18-dependent cell adhesion to fibrinogen (EC50 = 4 μM). Decreases leukocyte motility and transendothelial migration; reduces inflammation. Also activates complement receptor 3 (CR3), and promotes CR3-dependent leukocyte adhesion to fibrinogen-coated surfaces. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 421.49 |
| 分子式 | C22H15NO4S2< |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO with gentle warming |
| 参考文献 | Reedet al (2013) Complement receptor 3 influences Toll-like receptor 7/8-dependent inflammation. J.Biol.Chem. 288 9077. PMID: 23386618. Maiguelet al (2011) Small molecule-mediated activation of the integrin CD11b/CD18 reduces inflammatory disease. Sci.Signal. 4 1. PMID: 21900205. |