| 货号 | 4444/50 |
| 别名 | 4-[4-(4-Methylphenyl)-2-thiazolyl]- |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of sterol regulatory element binding protein (SREBP); impairs the activation of SREBP-1 and SREBP-2. Exhibits antiproliferative effects in DU 145 cells independently of IGF-1 signaling (IC50 = 0.1 μM); reverses hyperglycemia in diabetic (ob/ob) mice. Cell permeable. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >97 % |
| 计算分子量 | 375.33 |
| 分子式 | C18H18N2S.HBr |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO |
| 参考文献 | Kamisukiet al (2009) A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. Chem.Biol. 16 882. PMID: 19716478. Choiet al (2003) Identification of bioactive molecules by adipogenesis profiling of organic compounds. J.Biol.Chem. 278 7320. PMID: 12496288. |