| 货号 | 3733/50 |
| 别名 | 5-(5,5-Dimethyl-2-oxido-1,3,2-dioxa |
| 供应商 | Tocris |
| 生物活性 | Selective blocker of L-type and T-type Ca2+ channels. Displays minimal inhibition of N- and P/Q-type channels and no inhibition of R-type channels. R(-) and S(+)-enantiomers display different channel selectivity; S(+)-Efonidipine blocks L-type and T-type channels whereas R(-)-Efonidipine displays selectivity for T-type channels. Exhibits antihypertensive activity. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 714.18 |
| 分子式 | C34H38N3O7P.HCl.C2H5OH |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 111011-76-8 |
| 参考文献 | Shinet al (2008) A selective T-type Ca2+ channel blocker R(-) efonidipine. Naunyn-Schmied.Arch.Pharmacol. 377411. Furukawaet al (2004) Identification of R(-)-isomer of efonidipine as a selective blocker of T-type Ca2+ channels. Br.J.Pharmacol. 143 1050. PMID: 15545287. Masumiyaet al (1998) Inhibition of myocardial L- and T-type Ca2+ currents by efonidipine: possible mechanism for its chronotropic effect. Eur.J.Pharmacol. 349 351. PMID: 9671117. |