| 货号 | 3776/50 |
| 别名 | (R,R)-2-(4-Fluorophenyl)-β,δ-dihydrox |
| 供应商 | Tocris |
| 生物活性 | Potent HMG-CoA reductase inhibitor (IC50 = 8 nM). Reduces circulating LDL-C by inhibiting cholesterol biosynthesis and inducing expression of LDL receptors. Inhibits smooth muscle cell proliferation in vitro and exhibits antinociceptive effects in the inflammatory hypernociception model. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 577.67 |
| 分子式 | C33H34FN2O5.紺a |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 134523-03-8 |
| 参考文献 | Turneret al (2007) Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J.Cardiovasc.Pharmacol. 50 458. PMID: 18049315. Santodomingo-Garzonet al (2006) Atorvastatin inhibits inflammatory hypernociception. Br.J.Pharmacol. 149 14. PMID: 16865092. Vaughanet al (2004) Update on statins: 2003. Circulation 110 886. PMID: 15313959. Istvanet al (2001) Structural mechanism for statin inhibition of HMG-CoA reductase. Science 292 1160. PMID: 11349148. |