| 货号 | 2385/50 |
| 别名 | N,N'-Bis(diphenylmethyl)-1,2-ethaned |
| 供应商 | Tocris |
| 生物活性 | The first selective mGlu7 agonist. Potently inhibits cAMP accumulation and stimulates GTPγS binding in recombinant cells and on membranes expressing mGlu7(EC50 = 64 - 290 nM). Selective over other mGluR subtypes and selected ionotropic glutamate receptors up to 10 μM. Acts via a novel allosteric site and is orally active and brain penetrant. Reduces haloperidol-induced catalepsy in rats. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 465.45 |
| 分子式 | C28H28N2.2HCl |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 2 mM in water with gentle warming |
| CAS号 | 83027-13-8 |
| 参考文献 | Grecoet al (2010) Metabotropic glutamate 7 receptor subtype modulates motor symptoms in rodent models of Parkinson's disease. J.Pharmacol.Exp.Ther. 332 1064. PMID: 19940105. Floret al (2005) AMN082, the first selective mGluR7 agonist: activation of receptor signaling via an allosteric site in the transmembrane domain modulates stress parameters in vivo. Neuropharmacology 49 (Suppl. 1) 244. Mitsukawaet al (2005) A selective metabotropic glutamate receptor 7 agonist: Activation of receptor signaling via an allosteric site modulates stress parameters in vivo. Proc.Natl.Acad.Sci.USA 10218712. |