Fumitremorgin C
货号：
11030-1mg 基本售价：
6825.0 元 规格：
1 mg
产品信息
概述| 货号 | 11030-1mg |
| 描述 | Fumitremorgin C is a specific inhibitor of breast cancer resistance protein (BCRP/ABCG2) multidrug efflux transporter. At 5 μM, it significantly potentiates the toxicity of the chemotherapeutic drugs mitoxantrone, doxorubicin, and topotecan in S1-M1-3.2 colon carcinoma cells.1 Fumitremorgin C reverses multidrug resistance in cells overexpressing BCRP but not P-glycoprotein (ABCB1) or MRP1 (ABCC1).2,3 |
| 别名 | Tryptoquivaline; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Rabindran, S.K.,He, H.,Singh, M., et al. Reversal of a novel multidrug resistance mechanism in human colon carcinoma cells by fumitremorgin C. Cancer Research 58, 5850-5858 (1998).
2.Rabindran, S.K.,Ross, D.D.,Doyle, L.A., et al. Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein. Cancer Research 60, 47-50 (2000).
3.van Loevezijn, A.,Allen, J.D.,Schinkel, A.H., et al. Inhibition of BCRP-mediated drug efflux by fumitremorgin-type indolyl diketopiperazines. Bioorganic & Medicinal Chemistry Letters 11, 29-32 (2001).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 4 |
| 纯度 | ≥98% |
| 计算分子量 | 379.5 |
| 分子式 | C22H25N3O3 |
| CAS号 | 118974-02-0 |
| 稳定性 | ≥ 1 year |
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